Intervention strategies for ultra-high risk for psychosis: Progress in delaying the onset and reducing the impact of first-episode psychosis

Abstract

Over a quarter of a century ago, the formulation of the “at risk mental state” and operational criteria to prospectively identify individuals at “clinical” or “ultra-high risk” (UHR) for psychosis created a global wave of research momentum aimed at predicting and preventing first-episode psychosis. A substantial number of randomized controlled trials (RCTs) were conducted to determine if transition to psychosis could be delayed or even prevented. The efficacy of a range of interventions was examined, with standard meta-analyses clearly indicating that these could at least delay transition for 1–2 years and that outcomes improve. Recently, network meta-analyses have attempted to identify the ..